{
  "id": "SCR-LIP-000006",
  "statement": "For ultrasound diagnosis of lower-limb lipedema, subcutaneous thickness cutoffs of >11.7 mm (pre-tibial), >17.9 mm (anterior thigh), >8.4 mm (lateral leg) and >7.0 mm (medial supramalleolar) provide reproducible reference values.",
  "statement_pt": "Para o diagnóstico ultrassonográfico do lipedema, cortes de espessura subcutânea de >11,7 mm (pré-tibial), >17,9 mm (coxa anterior), >8,4 mm (perna lateral) e >7,0 mm (supramaleolar medial) fornecem valores de referência reprodutíveis.",
  "claim_type": "diagnostic",
  "context": {
    "population": "adult women evaluated for lipedema",
    "condition": "lipedema",
    "exposure": "high-frequency ultrasound",
    "comparator": "clinically diagnosed lipedema",
    "outcome": "reference cutoff values",
    "scope": "lower limbs, four points"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1177/02683555211002340",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": 89,
      "risk_of_bias": "moderate",
      "year": 2021,
      "amato_authored": true,
      "note": "Youden/ROC cutoffs; later reused by Vargas 2025 and Foureaux 2025"
    }
  ],
  "relations": [
    {
      "type": "diagnoses",
      "target_hint": "ultrasound cutoffs"
    }
  ],
  "gaps": "Derived from a single Brazilian cohort; no prospective multicenter validation.",
  "primary_amato_source": "DOI:10.1177/02683555211002340",
  "curators": [
    {
      "name": "Alexandre C. M. Amato",
      "orcid": "0000-0003-4008-4029",
      "role": "lead_curator"
    }
  ],
  "created": "2026-05-30",
  "updated": "2026-05-30",
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000003",
      "role": "supporting",
      "question": "Can ultrasound diagnose or classify lipedema?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000003.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000006.html"
}