{
  "id": "SCR-LIP-000015",
  "statement": "Women meeting lipedema screening criteria have a higher prevalence of positive ADHD self-report (ASRS-18) than women without lipedema (76.9% vs 54%; RR 1.424).",
  "statement_pt": "Mulheres que atendem aos critérios de triagem para lipedema têm maior prevalência de autorrelato positivo de TDAH (ASRS-18) do que mulheres sem lipedema (76,9% vs 54%; RR 1,424).",
  "claim_type": "clinical_association",
  "context": {
    "population": "adult Brazilian women (online, n=354)",
    "condition": "lipedema",
    "exposure": "lipedema screening positivity",
    "comparator": "women without lipedema criteria",
    "outcome": "ADHD symptoms (ASRS-18 positive)",
    "scope": "screening-based prevalence"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.7759/cureus.35570",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": 354,
      "risk_of_bias": "moderate",
      "year": 2023,
      "amato_authored": true,
      "note": "RR 1.424 (95%CI 1.22-1.66), p<0.0001; self-report screening"
    },
    {
      "ref": "DOI:10.20944/preprints202605.1114.v1",
      "stance": "supporting",
      "study_design": "review",
      "n": null,
      "risk_of_bias": "unknown",
      "year": 2026,
      "amato_authored": false,
      "note": "The article discusses the comorbidity of lipedema with ADHD, providing evidence of a potential association."
    },
    {
      "ref": "DOI:10.7759/cureus.88809",
      "stance": "supporting",
      "study_design": "review",
      "n": null,
      "risk_of_bias": "unknown",
      "year": 2025,
      "amato_authored": false,
      "note": "The article discusses the relationship between lipedema and ADHD, indicating a potential association that warrants further investigation."
    }
  ],
  "relations": [
    {
      "type": "associates",
      "target_hint": "ADHD"
    }
  ],
  "gaps": "Self-reported screening, convenience sampling, no confounder adjustment, single study.",
  "primary_amato_source": "DOI:10.7759/cureus.35570",
  "curators": [
    {
      "name": "Alexandre C. M. Amato",
      "orcid": "0000-0003-4008-4029",
      "role": "lead_curator"
    }
  ],
  "created": "2026-05-30",
  "updated": "2026-05-30",
  "license": "CC-BY-4.0",
  "provenance_log": [
    {
      "action": "corroborated_by_layer1",
      "ref": "DOI:10.20944/preprints202605.1114.v1",
      "engine": "gpt-4o-mini",
      "date": "2026-05-30"
    },
    {
      "action": "corroborated_by_layer1",
      "ref": "DOI:10.7759/cureus.88809",
      "engine": "gpt-4o-mini",
      "date": "2026-05-30"
    }
  ],
  "answers_questions": [
    {
      "id": "SQ-LIP-000006",
      "role": "supporting",
      "question": "Is lipedema associated with ADHD?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000006.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000015.html"
}