{
  "id": "SCR-LIP-000021",
  "statement": "Lipedema and fibromyalgia frequently co-occur: a cross-sectional study found lipedema in 50% of women meeting ACR fibromyalgia criteria, with longer fibromyalgia diagnostic delay and younger menarche as risk factors.",
  "statement_pt": "Lipedema e fibromialgia coocorrem com frequência: estudo transversal encontrou lipedema em 50% das mulheres com critérios ACR de fibromialgia, com maior tempo até o diagnóstico e menarca precoce como fatores de risco.",
  "claim_type": "clinical_association",
  "context": {
    "population": "adult women with fibromyalgia (ACR 2016, n=100)",
    "condition": "lipedema",
    "exposure": "fibromyalgia",
    "comparator": "fibromyalgia patients without lipedema",
    "outcome": "lipedema prevalence and risk factors",
    "scope": "prevalence within a fibromyalgia population"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1177/02683555251321042",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": 100,
      "risk_of_bias": "moderate",
      "year": 2025,
      "amato_authored": false,
      "note": "Gunaydin; lipedema in 50%; pain correlated with widespread pain r=0.62"
    }
  ],
  "relations": [
    {
      "type": "co_occurs",
      "target_hint": "fibromyalgia"
    }
  ],
  "gaps": "Single-center, no non-FM control; directionality unclear; not Amato-authored.",
  "primary_amato_source": "DOI:10.1177/02683555251321042",
  "curators": [
    {
      "name": "Alexandre C. M. Amato",
      "orcid": "0000-0003-4008-4029",
      "role": "lead_curator"
    }
  ],
  "created": "2026-05-30",
  "updated": "2026-05-30",
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000008",
      "role": "supporting",
      "question": "Is lipedema associated with fibromyalgia and other chronic-pain conditions?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000008.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000021.html"
}