{
  "id": "SCR-LIP-000023",
  "statement": "Women with clinically diagnosed lipedema show a higher prevalence of the celiac-associated HLA-DQ2/DQ8 haplotypes than the general population (any HLA 61.1% vs 53.7%; both haplotypes 7.4% vs 1.2%).",
  "statement_pt": "Mulheres com lipedema clinicamente diagnosticado apresentam maior prevalência dos haplótipos HLA-DQ2/DQ8 associados à celíaca do que a população geral (qualquer HLA 61,1% vs 53,7%; ambos 7,4% vs 1,2%).",
  "claim_type": "clinical_association",
  "context": {
    "population": "adult women with lipedema (Brazil), celiac excluded",
    "condition": "lipedema",
    "exposure": "lipedema phenotype",
    "comparator": "general/reference population HLA prevalence",
    "outcome": "HLA-DQ2/DQ8 carrier prevalence",
    "scope": "single-center cohort, n=95"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.7759/cureus.41594",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": 95,
      "risk_of_bias": "high",
      "year": 2023,
      "amato_authored": true,
      "note": "convenience sample; historical comparator (Cecilio 2015)"
    },
    {
      "ref": "DOI:10.1590/S0102-67202015000300009",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": 80,
      "risk_of_bias": "moderate",
      "year": 2015,
      "amato_authored": false,
      "note": "general-population HLA comparator"
    }
  ],
  "relations": [
    {
      "type": "associates",
      "target_hint": "HLA-DQ2/DQ8 susceptibility"
    }
  ],
  "gaps": "No concurrent control; selection bias toward symptomatic patients; cannot establish causation.",
  "primary_amato_source": "DOI:10.7759/cureus.41594",
  "curators": [
    {
      "name": "Alexandre C. M. Amato",
      "orcid": "0000-0003-4008-4029",
      "role": "lead_curator"
    }
  ],
  "created": "2026-05-30",
  "updated": "2026-05-30",
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000009",
      "role": "supporting",
      "question": "Is lipedema linked to gluten sensitivity, celiac disease, or HLA-DQ2/DQ8?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000009.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000023.html"
}