{
  "id": "SCR-LIP-000024",
  "statement": "In women with lipedema, food-specific IgG testing shows a paradox: a slightly higher number of positive food reactions despite markedly lower total IgG (1747 vs 2975 AU; p<0.001).",
  "statement_pt": "Em mulheres com lipedema, o teste de IgG alimentar mostra paradoxo: número discretamente maior de reações positivas apesar de IgG total marcadamente menor (1747 vs 2975 UA; p<0,001).",
  "claim_type": "clinical_association",
  "context": {
    "population": "adult women with vs without lipedema (Brazil)",
    "condition": "lipedema",
    "exposure": "lipedema phenotype",
    "comparator": "women without lipedema",
    "outcome": "food-specific IgG positivity and total IgG",
    "scope": "retrospective cross-sectional"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.7759/cureus.93788",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": 234,
      "risk_of_bias": "high",
      "year": 2025,
      "amato_authored": true,
      "note": "higher positive count NS (p=0.186); lower total IgG highly significant"
    }
  ],
  "relations": [
    {
      "type": "associates",
      "target_hint": "mucosal/humoral immune dysregulation"
    }
  ],
  "gaps": "IgG subclasses not measured; possible diet/elimination confounding; food-IgG clinical meaning controversial.",
  "primary_amato_source": "DOI:10.7759/cureus.93788",
  "curators": [
    {
      "name": "Alexandre C. M. Amato",
      "orcid": "0000-0003-4008-4029",
      "role": "lead_curator"
    }
  ],
  "created": "2026-05-30",
  "updated": "2026-05-30",
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000009",
      "role": "context",
      "question": "Is lipedema linked to gluten sensitivity, celiac disease, or HLA-DQ2/DQ8?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000009.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000024.html"
}