{
  "id": "SCR-LIP-000025",
  "statement": "In a nationally representative NHANES sample, women with serologically confirmed celiac disease had significantly lower gynoid percent fat than non-celiac women (39.5% vs 42.6%; -7.4%; p=0.0007).",
  "statement_pt": "Em amostra nacionalmente representativa (NHANES), mulheres com doença celíaca confirmada tiveram percentual de gordura ginoide significativamente menor que não celíacas (39,5% vs 42,6%; -7,4%; p=0,0007).",
  "claim_type": "clinical_association",
  "context": {
    "population": "US women >=20y (NHANES 2011-2014)",
    "condition": "lipedema",
    "exposure": "celiac disease autoimmunity",
    "comparator": "non-celiac women",
    "outcome": "gynoid percent fat (DXA)",
    "scope": "cross-sectional, n=3833 (11 celiac)"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.64898/2025.12.01.25341350",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": 3833,
      "risk_of_bias": "moderate",
      "year": 2025,
      "amato_authored": true,
      "note": "only 11 celiac cases; ethnic imbalance; cross-sectional"
    },
    {
      "ref": "DOI:10.7759/cureus.104222",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": 3833,
      "risk_of_bias": "moderate",
      "year": 2026,
      "amato_authored": true,
      "note": "peer-reviewed version, same dataset"
    }
  ],
  "relations": [
    {
      "type": "associates",
      "target_hint": "celiac vs gynoid adiposity"
    }
  ],
  "gaps": "Reverse causation partly addressed by BMI strata; n=11 precludes adjustment; DXA proxy not validated against clinical lipedema.",
  "primary_amato_source": "DOI:10.64898/2025.12.01.25341350",
  "curators": [
    {
      "name": "Alexandre C. M. Amato",
      "orcid": "0000-0003-4008-4029",
      "role": "lead_curator"
    }
  ],
  "created": "2026-05-30",
  "updated": "2026-05-30",
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000009",
      "role": "supporting",
      "question": "Is lipedema linked to gluten sensitivity, celiac disease, or HLA-DQ2/DQ8?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000009.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000025.html"
}