{
  "id": "SCR-LIP-000026",
  "statement": "The reduced gynoid adiposity associated with celiac disease in NHANES persisted among overweight/obese women (-8.7% overall, p=0.005; -11.3% in obese, p=0.039), arguing against leanness/malnutrition as the sole explanation.",
  "statement_pt": "A redução de gordura ginoide associada à celíaca no NHANES persistiu em mulheres com sobrepeso/obesidade (-8,7% geral, p=0,005; -11,3% em obesas, p=0,039), contra magreza/desnutrição como única explicação.",
  "claim_type": "clinical_association",
  "context": {
    "population": "overweight/obese US women (NHANES)",
    "condition": "lipedema",
    "exposure": "celiac disease autoimmunity",
    "comparator": "non-celiac overweight/obese women",
    "outcome": "gynoid percent fat, BMI-stratified",
    "scope": "cross-sectional sensitivity analysis, n=2503 (7 celiac)"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.64898/2025.12.01.25341350",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": 2503,
      "risk_of_bias": "high",
      "year": 2025,
      "amato_authored": true,
      "note": "only 7 celiac cases in stratum; estimates unstable"
    }
  ],
  "relations": [
    {
      "type": "contextualizes",
      "target_hint": "leanness-bias control"
    }
  ],
  "gaps": "Extremely small cell counts; cannot exclude all reverse causation.",
  "primary_amato_source": "DOI:10.64898/2025.12.01.25341350",
  "curators": [
    {
      "name": "Alexandre C. M. Amato",
      "orcid": "0000-0003-4008-4029",
      "role": "lead_curator"
    }
  ],
  "created": "2026-05-30",
  "updated": "2026-05-30",
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000009",
      "role": "supporting",
      "question": "Is lipedema linked to gluten sensitivity, celiac disease, or HLA-DQ2/DQ8?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000009.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000026.html"
}