{
  "id": "SCR-LIP-000027",
  "statement": "In NHANES women, a DXA-defined lipedema-like phenotype (leg-to-trunk fat ratio >90th percentile) was associated with a favorable immunometabolic profile, including 44.2% lower HOMA-IR (p<0.001) and 7.6% lower neutrophil-to-lymphocyte ratio (p=0.012).",
  "statement_pt": "Em mulheres do NHANES, o fenótipo tipo-lipedema por DXA (razão gordura perna/tronco >p90) associou-se a perfil imunometabólico favorável, incluindo HOMA-IR 44,2% menor (p<0,001) e relação neutrófilo-linfócito 7,6% menor (p=0,012).",
  "claim_type": "clinical_association",
  "context": {
    "population": "US women >=20y (NHANES)",
    "condition": "lipedema",
    "exposure": "lipedema-like phenotype (LTR >90th pct)",
    "comparator": "controls (LTR <=90th pct)",
    "outcome": "HOMA-IR, NLR",
    "scope": "cross-sectional, n=283 phenotype / 3550 controls"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.64898/2025.12.01.25341350",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": 3833,
      "risk_of_bias": "moderate",
      "year": 2025,
      "amato_authored": true,
      "note": "exploratory; DXA proxy may capture gynoid obesity"
    }
  ],
  "relations": [
    {
      "type": "associates",
      "target_hint": "peripheral fat as metabolic sink"
    }
  ],
  "gaps": "Phenotype proxy unvalidated against clinical lipedema; possible misclassification; no causal direction.",
  "primary_amato_source": "DOI:10.64898/2025.12.01.25341350",
  "curators": [
    {
      "name": "Alexandre C. M. Amato",
      "orcid": "0000-0003-4008-4029",
      "role": "lead_curator"
    }
  ],
  "created": "2026-05-30",
  "updated": "2026-05-30",
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000010",
      "role": "supporting",
      "question": "Does a lipedema-like (peripheral/gynoid) fat distribution protect against cancer or metabolic disease?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000010.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000027.html"
}