{
  "id": "SCR-LIP-000028",
  "statement": "In NHANES women aged 20-59, a lipedema-like peripheral fat distribution was inversely associated with cancer prevalence: each 1-SD increase in leg-to-trunk fat ratio was associated with 20% lower adjusted odds of cancer (OR 0.795; 95%CI 0.666-0.948; p=0.011).",
  "statement_pt": "Em mulheres do NHANES de 20-59 anos, a distribuição periférica de gordura tipo-lipedema associou-se inversamente à prevalência de câncer: cada +1-DP na razão perna/tronco associou-se a chance ajustada de câncer 20% menor (OR 0,795; IC95% 0,666-0,948; p=0,011).",
  "claim_type": "epidemiologic",
  "context": {
    "population": "US women 20-59 (NHANES)",
    "condition": "lipedema",
    "exposure": "leg-to-trunk fat ratio (per 1-SD)",
    "comparator": "lower LTR (more central fat)",
    "outcome": "self-reported cancer prevalence",
    "scope": "cross-sectional, n=2818 (130 cancer)"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.64898/2025.12.02.25341445",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": 2818,
      "risk_of_bias": "moderate",
      "year": 2025,
      "amato_authored": true,
      "note": "prevalence/survivorship not incidence; reverse causation possible; E-value 1.83"
    }
  ],
  "relations": [
    {
      "type": "associates",
      "target_hint": "peripheral adiposity and lower cancer prevalence"
    }
  ],
  "gaps": "Cross-sectional prevalence not incidence; self-reported; residual confounding; cannot distinguish clinical lipedema from peripheral obesity.",
  "primary_amato_source": "DOI:10.64898/2025.12.02.25341445",
  "curators": [
    {
      "name": "Alexandre C. M. Amato",
      "orcid": "0000-0003-4008-4029",
      "role": "lead_curator"
    }
  ],
  "created": "2026-05-30",
  "updated": "2026-05-30",
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000010",
      "role": "supporting",
      "question": "Does a lipedema-like (peripheral/gynoid) fat distribution protect against cancer or metabolic disease?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000010.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000028.html"
}