{
  "id": "SCR-LIP-000029",
  "statement": "The inverse association between lipedema-like peripheral fat distribution and cancer prevalence was most robust in women without obesity (OR 0.67 per 1-SD LTR; 95%CI 0.53-0.85; p=0.0007).",
  "statement_pt": "A associação inversa entre distribuição periférica tipo-lipedema e prevalência de câncer foi mais robusta em mulheres sem obesidade (OR 0,67 por 1-DP de LTR; IC95% 0,53-0,85; p=0,0007).",
  "claim_type": "epidemiologic",
  "context": {
    "population": "US women 20-59 stratified by obesity (NHANES)",
    "condition": "lipedema",
    "exposure": "leg-to-trunk fat ratio (per 1-SD)",
    "comparator": "lower LTR within obesity stratum",
    "outcome": "cancer prevalence",
    "scope": "cross-sectional subgroup, n=2818"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.64898/2025.12.02.25341445",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": 2818,
      "risk_of_bias": "moderate",
      "year": 2025,
      "amato_authored": true,
      "note": "interaction by obesity NS (p=0.58); E-value 2.34 non-obese"
    }
  ],
  "relations": [
    {
      "type": "associates",
      "target_hint": "peripheral fat protection in non-obese women"
    }
  ],
  "gaps": "Underpowered obesity subgroup; survivorship bias; no incidence data.",
  "primary_amato_source": "DOI:10.64898/2025.12.02.25341445",
  "curators": [
    {
      "name": "Alexandre C. M. Amato",
      "orcid": "0000-0003-4008-4029",
      "role": "lead_curator"
    }
  ],
  "created": "2026-05-30",
  "updated": "2026-05-30",
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000010",
      "role": "supporting",
      "question": "Does a lipedema-like (peripheral/gynoid) fat distribution protect against cancer or metabolic disease?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000010.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000029.html"
}