{
  "id": "SCR-LIP-000039",
  "statement": "In women with lipedema, hormonal contraceptive use is associated with self-reported symptom worsening (58.8% of users; 15.1% reporting symptom onset coinciding with contraceptive initiation).",
  "statement_pt": "Em mulheres com lipedema, o uso de anticoncepcionais hormonais associa-se a piora autorrelatada dos sintomas (58,8% das usuárias; 15,1% com início dos sintomas coincidindo com o início do contraceptivo).",
  "claim_type": "clinical_association",
  "context": {
    "population": "637 Brazilian women, suspected/confirmed lipedema",
    "condition": "lipedema",
    "exposure": "hormonal contraceptive use",
    "comparator": "no worsening / non-users",
    "outcome": "self-reported symptom worsening",
    "scope": "observational self-report, Brazil"
  },
  "knowledge_state": "probable",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.7759/cureus.99189",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": 637,
      "risk_of_bias": "moderate",
      "year": 2025,
      "amato_authored": true,
      "note": "chi2=213.71 p<0.001; baseline symptom burden strongest predictor; recall/selection bias"
    }
  ],
  "relations": [
    {
      "type": "associates",
      "target_hint": "estrogenic trigger"
    }
  ],
  "gaps": "Self-reported, cross-sectional, social-media-recruited; recall bias; no objective measures.",
  "primary_amato_source": "DOI:10.7759/cureus.99189",
  "curators": [
    {
      "name": "Alexandre C. M. Amato",
      "orcid": "0000-0003-4008-4029",
      "role": "lead_curator"
    }
  ],
  "created": "2026-05-30",
  "updated": "2026-05-30",
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000012",
      "role": "supporting",
      "question": "Do hormones and heredity influence the onset of lipedema?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000012.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000039.html"
}