{
  "id": "SCR-LIP-000042",
  "statement": "Lipedema gluteofemoral adipose tissue displays a dominant M2 macrophage transcriptomic signature with CD163+ macrophage enrichment (2.58-fold by qPCR; 1171 differentially expressed genes), indicating a type-2 immune microenvironment.",
  "statement_pt": "O tecido adiposo gluteofemoral do lipedema exibe assinatura transcriptômica dominante de macrófagos M2 com enriquecimento de CD163+ (2,58 vezes por qPCR; 1171 genes diferencialmente expressos), indicando microambiente imune tipo 2.",
  "claim_type": "clinical_association",
  "context": {
    "population": "patients with lipedema",
    "condition": "lipedema",
    "exposure": "lipedema gfWAT",
    "comparator": "control / abdominal subcutaneous fat / lymphedema",
    "outcome": "M2/CD163+ macrophage enrichment",
    "scope": "gluteofemoral adipose tissue"
  },
  "knowledge_state": "probable",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.3389/fimmu.2022.1004609",
      "stance": "supporting",
      "study_design": "basic_science",
      "n": null,
      "risk_of_bias": "moderate",
      "year": 2022,
      "amato_authored": false,
      "note": "Wolf et al.; CyTOF + RNA-seq; in vitro functional causality (IPI-549)"
    }
  ],
  "relations": [
    {
      "type": "associates",
      "target_hint": "type-2 immune polarization"
    }
  ],
  "gaps": "Cellular source of IL-4/IL-13 not directly identified; mast-cell- vs hypoxia-driven not resolved.",
  "primary_amato_source": "DOI:10.3389/fimmu.2022.1004609",
  "curators": [
    {
      "name": "Alexandre C. M. Amato",
      "orcid": "0000-0003-4008-4029",
      "role": "lead_curator"
    }
  ],
  "created": "2026-05-30",
  "updated": "2026-05-30",
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000011",
      "role": "supporting",
      "question": "What is known about the inflammation and pain mechanism in lipedema tissue?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000011.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000042.html"
}