{
  "id": "SCR-LIP-000043",
  "statement": "Lipedema has a distinctive quantitative sensory testing (QST) signature in the affected limb — isolated lowered pressure pain threshold and raised vibration detection threshold with spared thermal thresholds — yielding high diagnostic accuracy (PVTH-score AUC 0.958).",
  "statement_pt": "O lipedema tem assinatura distintiva de teste sensorial quantitativo (QST) no membro acometido — limiar de dor à pressão reduzido e limiar de detecção vibratória elevado isolados, com limiares térmicos preservados — com alta acurácia diagnóstica (PVTH-score AUC 0,958).",
  "claim_type": "diagnostic",
  "context": {
    "population": "non-obese women with lipedema",
    "condition": "lipedema",
    "exposure": "DFNS quantitative sensory testing",
    "comparator": "unaffected site / controls",
    "outcome": "selective QST abnormality (PPT-down, VDT-up)",
    "scope": "peripheral sensory phenotype, affected limb"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1097/PR9.0000000000001155",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "moderate",
      "year": 2024,
      "amato_authored": false,
      "note": "Dinnendahl/Bertsch; only PPT-down and VDT-up of 13 parameters; pattern in thigh, absent in hand"
    }
  ],
  "relations": [
    {
      "type": "associates",
      "target_hint": "lipedema pain phenotype"
    }
  ],
  "gaps": "Single study; mechanism of the pattern not established; needs independent replication.",
  "primary_amato_source": "DOI:10.1097/PR9.0000000000001155",
  "curators": [
    {
      "name": "Alexandre C. M. Amato",
      "orcid": "0000-0003-4008-4029",
      "role": "lead_curator"
    }
  ],
  "created": "2026-05-30",
  "updated": "2026-05-30",
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000011",
      "role": "supporting",
      "question": "What is known about the inflammation and pain mechanism in lipedema tissue?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000011.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000043.html"
}