{
  "id": "SCR-LIP-000044",
  "statement": "Lipedema is defined by a disproportionate, symmetrical accumulation of subcutaneous adipose tissue in the limbs relative to the trunk that is characteristically resistant to conventional weight-loss methods (diet and exercise), distinguishing it from common obesity.",
  "statement_pt": "O lipedema define-se por acúmulo desproporcional e simétrico de tecido adiposo subcutâneo nos membros em relação ao tronco, caracteristicamente resistente a métodos convencionais de perda de peso (dieta e exercício), distinguindo-o da obesidade comum.",
  "claim_type": "definitional",
  "context": {
    "population": "adults with lipedema",
    "condition": "lipedema",
    "exposure": "",
    "comparator": "common obesity",
    "outcome": "disproportionate, weight-loss-resistant limb fat",
    "scope": "disease definition (Brazilian consensus)"
  },
  "knowledge_state": "established",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1590/1677-5449.202301832",
      "stance": "supporting",
      "study_design": "consensus",
      "n": 113,
      "risk_of_bias": "moderate",
      "year": 2025,
      "amato_authored": true,
      "note": "Brazilian Delphi consensus; agreement 4.29 (disproportion) and 4.51 (differentiation/weight-loss resistance); level B/C — expert agreement, not primary evidence"
    }
  ],
  "relations": [
    {
      "type": "contextualizes",
      "target_hint": "obesity differential"
    }
  ],
  "gaps": "Consensus-level statement (level B/C); the weight-loss resistance is clinically observed, not quantified in controlled trials.",
  "primary_amato_source": "DOI:10.1590/1677-5449.202301832",
  "curators": [
    {
      "name": "Alexandre C. M. Amato",
      "orcid": "0000-0003-4008-4029",
      "role": "lead_curator"
    }
  ],
  "created": "2026-05-30",
  "updated": "2026-05-30",
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000001",
      "role": "supporting",
      "question": "Is lipedema a distinct disease, separate from obesity and lymphedema?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000001.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000044.html"
}