{
  "id": "SCR-LIP-000046",
  "statement": "Several findings suggest a hereditary predisposition to lipedema, with frequent family history among affected women.",
  "statement_pt": "Vários achados sugerem predisposição hereditária ao lipedema, com história familiar frequente entre as mulheres acometidas.",
  "claim_type": "causal",
  "context": {
    "population": "women with lipedema",
    "condition": "lipedema",
    "exposure": "family history / genetic predisposition",
    "comparator": "",
    "outcome": "hereditary predisposition",
    "scope": "etiology (consensus)"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1590/1677-5449.202301832",
      "stance": "supporting",
      "study_design": "consensus",
      "n": 113,
      "risk_of_bias": "moderate",
      "year": 2025,
      "amato_authored": true,
      "note": "consensus agreement 4.26, level B; 'lipedema is hereditary'"
    }
  ],
  "relations": [
    {
      "type": "associates",
      "target_hint": "genetic/hereditary predisposition"
    }
  ],
  "gaps": "Specific genes and inheritance pattern not established; based on family history and expert consensus.",
  "primary_amato_source": "DOI:10.1590/1677-5449.202301832",
  "curators": [
    {
      "name": "Alexandre C. M. Amato",
      "orcid": "0000-0003-4008-4029",
      "role": "lead_curator"
    }
  ],
  "created": "2026-05-30",
  "updated": "2026-05-30",
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000012",
      "role": "supporting",
      "question": "Do hormones and heredity influence the onset of lipedema?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000012.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000046.html"
}