{
  "id": "SCR-LIP-000051",
  "statement": "Lipedema was first delineated as a distinct clinical syndrome by Allen and Hines at the Mayo Clinic in 1940, who coined the term and described the disproportionate, bilateral, foot-sparing leg fat with edema that defines it.",
  "statement_pt": "O lipedema foi delineado pela primeira vez como síndrome clínica distinta por Allen e Hines, na Mayo Clinic, em 1940, que cunharam o termo e descreveram a gordura desproporcional, bilateral e poupadora dos pés, com edema, que o define.",
  "claim_type": "historical",
  "context": {
    "population": "patients with lipedema / disproportionate gynoid fat (historical)",
    "condition": "lipedema",
    "exposure": "first clinical description (1940)",
    "comparator": "n/a (historical landmark)",
    "outcome": "description / surgical treatment",
    "scope": "historical record"
  },
  "knowledge_state": "established",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "Allen EV, Hines EA Jr. Lipedema of the legs: a syndrome characterized by fat legs and edema. Proc Staff Meet Mayo Clin 1940;15:184-7",
      "stance": "supporting",
      "study_design": "clinical_description",
      "n": null,
      "risk_of_bias": "high",
      "year": 1940,
      "amato_authored": false,
      "note": "Original description; coined the term 'lipedema'. Pre-MEDLINE (no DOI/PMID)."
    }
  ],
  "relations": [],
  "gaps": "Historical descriptive report predating modern diagnostic criteria and imaging.",
  "primary_amato_source": null,
  "curators": [
    {
      "name": "Alexandre C. M. Amato",
      "orcid": "0000-0003-4008-4029",
      "role": "lead_curator"
    }
  ],
  "created": "2026-05-30",
  "updated": "2026-05-30",
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000019",
      "role": "supporting",
      "question": "What are the historical milestones in the description and surgical treatment of lipedema?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000019.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000051.html"
}