{
  "id": "SCR-LIP-000052",
  "statement": "The clinical syndrome was consolidated in 1951 when Wold, Hines and Allen reported a large case series (about 119 patients) detailing lipedema's orthostatic edema, pain and strong predominance in women.",
  "statement_pt": "A síndrome clínica foi consolidada em 1951, quando Wold, Hines e Allen relataram uma grande série de casos (cerca de 119 pacientes), detalhando o edema ortostático, a dor e a forte predominância no sexo feminino do lipedema.",
  "claim_type": "historical",
  "context": {
    "population": "patients with lipedema / disproportionate gynoid fat (historical)",
    "condition": "lipedema",
    "exposure": "first large case series (1951)",
    "comparator": "n/a (historical landmark)",
    "outcome": "description / surgical treatment",
    "scope": "historical record"
  },
  "knowledge_state": "established",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "Wold LE, Hines EA Jr, Allen EV. Lipedema of the legs: a syndrome characterized by fat legs and orthostatic edema. Ann Intern Med 1951;34(5):1243-50",
      "stance": "supporting",
      "study_design": "case_series",
      "n": 119,
      "risk_of_bias": "high",
      "year": 1951,
      "amato_authored": false,
      "note": "First large clinical series (~119 patients). Early-MEDLINE; cited bibliographically."
    }
  ],
  "relations": [],
  "gaps": "Uncontrolled historical case series; predates modern criteria.",
  "primary_amato_source": null,
  "curators": [
    {
      "name": "Alexandre C. M. Amato",
      "orcid": "0000-0003-4008-4029",
      "role": "lead_curator"
    }
  ],
  "created": "2026-05-30",
  "updated": "2026-05-30",
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000019",
      "role": "supporting",
      "question": "What are the historical milestones in the description and surgical treatment of lipedema?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000019.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000052.html"
}