{
  "id": "SCR-LIP-000076",
  "statement": "In a national survey of 707 U.S. women with lipedema, the mean age was 48.6 years and mean BMI was 40.9 kg/m², with symptom onset most commonly at puberty (48.0%) or pregnancy (41.2%), and the condition exclusively affected women in this sample.",
  "statement_pt": "Em uma pesquisa nacional com 707 mulheres americanas com lipedema, a média de idade foi de 48,6 anos e o IMC médio foi de 40,9 kg/m², com início dos sintomas mais frequentemente na puberdade (48,0%) ou na gravidez (41,2%), e a condição afetou exclusivamente mulheres nesta amostra.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.1177/1358863x231202769",
      "stance": "context",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "year": 2024,
      "amato_authored": false,
      "note": "The survey provides demographic and clinical characteristics of a large U.S. lipedema cohort, offering context on who is affected and when symptoms begin, but does not report population prevalence estimates.",
      "title": "National survey of patient symptoms and therapies among 707 women with a lipedema phenotype in the United States",
      "authors": "Aday et al.",
      "journal": "Vascular Medicine"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-sonnet-4.6",
    "question": "SQ-LIP-000002",
    "source": "europepmc",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000002",
      "role": "context",
      "question": "How common is lipedema, and who does it affect?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000002.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000076.html"
}