{
  "id": "SCR-LIP-000080",
  "statement": "In a Swiss referral centre cohort of 381 women with lipedema (mean age 41.9 years), 49.9% reported a family history, 62.2% reported symptom onset during adolescence, and 92.1% had comorbidities, with pain affecting 87.9% and significantly reduced quality of life in the majority.",
  "statement_pt": "Em uma coorte de 381 mulheres com lipedema (idade média 41,9 anos) em um centro de referência suíço, 49,9% relataram histórico familiar, 62,2% relataram início dos sintomas na adolescência, 92,1% apresentavam comorbidades, dor afetava 87,9% e a maioria relatou qualidade de vida significativamente reduzida.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.1371/journal.pone.0319099",
      "stance": "context",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "year": 2025,
      "amato_authored": false,
      "note": "This retrospective cross-sectional study from a single referral centre provides detailed epidemiological and clinical characteristics of lipedema patients (all female, referral bias), addressing who is affected and clinical burden, but does",
      "title": "Clinical characteristics, comorbidities, and correlation with advanced lipedema stages: A retrospective study from a Swiss referral centre",
      "authors": "Luta et al.",
      "journal": "PLOS ONE"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-sonnet-4.6",
    "question": "SQ-LIP-000002",
    "source": "europepmc",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000002",
      "role": "context",
      "question": "How common is lipedema, and who does it affect?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000002.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000080.html"
}