{
  "id": "SCR-LIP-000082",
  "statement": "A scoping review of 25 studies from 10 countries characterizes lipedema as a systemic condition affecting women with symptom onset linked to reproductive milestones and a high frequency of gynecologic and endocrine comorbidities, reflecting a shift toward an endocrinometabolic framework.",
  "statement_pt": "Uma revisão de escopo com 25 estudos de 10 países caracteriza a lipedema como uma condição sistêmica que afeta mulheres, com início dos sintomas associado a marcos reprodutivos e alta frequência de comorbidades ginecológicas e endócrinas, refletindo uma mudança em direção a um modelo endocrinometabólico.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.3390/biomedicines14010122",
      "stance": "context",
      "study_design": "review",
      "n": null,
      "risk_of_bias": "unknown",
      "year": 2026,
      "amato_authored": false,
      "note": "The scoping review provides contextual epidemiological and pathophysiological information about who lipedema affects (women, linked to reproductive milestones) but does not report specific prevalence figures or population-level incidence da",
      "title": "Lipedema in Women and Its Interrelationship with Endometriosis and Other Gynecologic Diseases: A Scoping Review",
      "authors": "Viana et al.",
      "journal": "Biomedicines"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-sonnet-4.6",
    "question": "SQ-LIP-000002",
    "source": "europepmc",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000002",
      "role": "context",
      "question": "How common is lipedema, and who does it affect?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000002.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000082.html"
}