{
  "id": "SCR-LIP-000104",
  "statement": "In a cross-sectional survey of 354 women with lipedema, 35% (124/354) met ACR 2016 diagnostic criteria for fibromyalgia syndrome, and those with fibromyalgia had significantly higher anxiety, depression, and impaired quality of life compared to those without.",
  "statement_pt": "Em um estudo transversal com 354 mulheres com lipedema, 35% (124/354) atenderam aos critérios diagnósticos ACR 2016 para síndrome de fibromialgia, e aquelas com fibromialgia apresentaram níveis significativamente maiores de ansiedade, depressão e pior qualidade de vida em comparação às sem fibromialgia.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.1089/lrb.2023.0038",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "year": 2024,
      "amato_authored": false,
      "note": "The study directly measures fibromyalgia prevalence in a lipedema population using validated diagnostic criteria (ACR 2016), finding a 35% comorbidity rate. Limitations include self-reported data via online survey and potential selection bi",
      "title": "Prevalence of Fibromyalgia Syndrome in Women with Lipedema and Its Effect on Anxiety, Depression, and Quality of Life",
      "authors": "Cagliyan Turk et al.",
      "journal": "Lymphatic Research and Biology"
    },
    {
      "ref": "DOI:10.2147/jpr.s315736",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "year": 2021,
      "amato_authored": false,
      "note": "Direct empirical comparison of fibromyalgia and lipedema cohorts with validated instruments; cross-sectional design limits causal inference, but the 34% comorbidity rate and phenotypic overlap data directly address the association between l",
      "title": "Common and Contrasting Characteristics of the Chronic Soft-Tissue Pain Conditions Fibromyalgia and Lipedema",
      "authors": "Angst et al.",
      "journal": "Journal of Pain Research"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-sonnet-4.6",
    "question": "SQ-LIP-000008",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "license": "CC-BY-4.0",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created"
    },
    {
      "date": "2026-05-31",
      "event": "corroborated_by_layer1",
      "detail": "DOI:10.2147/jpr.s315736"
    }
  ],
  "answers_questions": [
    {
      "id": "SQ-LIP-000008",
      "role": "supporting",
      "question": "Is lipedema associated with fibromyalgia and other chronic-pain conditions?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000008.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000104.html"
}