{
  "id": "SCR-LIP-000105",
  "statement": "In a cross-sectional study comparing lipedema patients to sex-, age-, and BMI-matched population controls, 100% of lipedema patients reported pain (vs. 70.8% of controls), with 43.2% reporting severe pain-related disability in daily activities vs. 9.2% of controls, and strong correlation between pain severity and depressive symptoms (rho=0.612, p<0.001).",
  "statement_pt": "Em estudo transversal comparando pacientes com lipedema a controles populacionais pareados por sexo, idade e IMC, 100% das pacientes com lipedema relataram dor (vs. 70,8% dos controles), com 43,2% relatando incapacidade grave relacionada à dor nas atividades diárias vs. 9,2% dos controles, e forte correlação entre intensidade da dor e sintomas depressivos (rho=0,612, p<0,001).",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.3390/life14030295",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "year": 2024,
      "amato_authored": false,
      "note": "The article directly addresses chronic pain burden in lipedema versus matched controls, demonstrating significantly higher pain prevalence and severity, supporting the association between lipedema and chronic pain conditions; however, it do",
      "title": "Health Implications of Lipedema: Analysis of Patient Questionnaires and Population-Based Matched Controls",
      "authors": "Kempa et al.",
      "journal": "Life"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-sonnet-4.6",
    "question": "SQ-LIP-000008",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "license": "CC-BY-4.0",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created"
    }
  ],
  "answers_questions": [
    {
      "id": "SQ-LIP-000008",
      "role": "supporting",
      "question": "Is lipedema associated with fibromyalgia and other chronic-pain conditions?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000008.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000105.html"
}