{
  "id": "SCR-LIP-000123",
  "statement": "Lymphoscintigraphy in 19 lipedema patients revealed pathologic lymphatic transport (TI >10) in 63.2% of lower extremities, with significantly higher transport index scores in severe (stage 3/4) versus mild/moderate (stage 1/2) lipedema (mean TI 15.1 vs 9.7, p=0.049), indicating progressive lymphatic dysfunction associated with clinical severity.",
  "statement_pt": "A linfocintilografia em 19 pacientes com lipedema revelou transporte linfático patológico (TI >10) em 63,2% dos membros inferiores, com escores de índice de transporte significativamente maiores no lipedema grave (estágios 3/4) em comparação ao leve/moderado (estágios 1/2) (TI médio 15,1 vs 9,7, p=0,049), indicando disfunção linfática progressiva associada à gravidade clínica.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.1055/s-0039-1697904",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "year": 2019,
      "amato_authored": false,
      "note": "This cross-sectional study directly addresses lymphatic dysfunction in lipedema and its association with clinical staging, providing objective lymphoscintigraphic evidence that lymphatic transport abnormalities worsen with lipedema severity",
      "title": "Uncovering Lymphatic Transport Abnormalities in Patients with Primary Lipedema",
      "authors": "Gould et al.",
      "journal": "Journal of Reconstructive Microsurgery"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-sonnet-4.6",
    "question": "SQ-LIP-000017",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "license": "CC-BY-4.0",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created"
    }
  ],
  "answers_questions": [
    {
      "id": "SQ-LIP-000017",
      "role": "supporting",
      "question": "Does lipedema progress to lymphedema and cause functional disability?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000017.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000123.html"
}