{
  "id": "SCR-LIP-000127",
  "statement": "In 258 women with lipedema, the prevalence of clinical lower limb lymphedema increased progressively with BMI: 6.1% in BMI <30, 51.6% in BMI 30–40, and 77.8% in BMI 40–50 kg/m², with statistically significant differences between groups (p=0.0001).",
  "statement_pt": "Em 258 mulheres com lipedema, a prevalência de linfedema clínico dos membros inferiores aumentou progressivamente com o IMC: 6,1% no IMC <30, 51,6% no IMC 30–40 e 77,8% no IMC 40–50 kg/m², com diferenças estatisticamente significativas entre os grupos (p=0,0001).",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.7759/cureus.11854",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "year": 2020,
      "amato_authored": false,
      "note": "Cross-sectional design with bioimpedance-based lymphedema detection in a reasonably large sample (n=258) demonstrates a dose-response gradient between obesity and lymphedema prevalence in lipedema patients, directly supporting progression f",
      "title": "Lipedema and the Evolution to Lymphedema With the Progression of Obesity",
      "authors": "Pereira de Godoy et al.",
      "journal": "Cureus"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-sonnet-4.6",
    "question": "SQ-LIP-000017",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "license": "CC-BY-4.0",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created"
    }
  ],
  "answers_questions": [
    {
      "id": "SQ-LIP-000017",
      "role": "supporting",
      "question": "Does lipedema progress to lymphedema and cause functional disability?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000017.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000127.html"
}