{
  "id": "SCR-LIP-000134",
  "statement": "In a survey of 209 German women with lipedema who underwent liposuction, hypothyroidism was present in 35.9% of participants, a frequency described as far beyond the average prevalence in the general German population.",
  "statement_pt": "Em uma pesquisa com 209 mulheres alemãs com lipedema submetidas à lipoaspiração, o hipotireoidismo estava presente em 35,9% das participantes, frequência descrita como muito superior à prevalência média na população geral alemã.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1097/prs.0000000000006280",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2019,
      "amato_authored": false,
      "note": "The study reports a high prevalence of hypothyroidism in lipedema patients compared to the general population, directly supporting an association between lipedema and thyroid disease; however, confidence is limited by the self-selected onli",
      "title": "New Insights on Lipedema: The Enigmatic Disease of the Peripheral Fat",
      "authors": "Bauer et al.",
      "journal": "Plastic & Reconstructive Surgery"
    },
    {
      "ref": "DOI:10.1111/dth.14534",
      "stance": "supporting",
      "study_design": "cohort",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2020,
      "amato_authored": false,
      "note": "The study reports increased prevalence of hypothyroidism in lipedema patients compared to general population, directly supporting the association, but is limited by retrospective design, lack of a matched control group, and reliance on self",
      "title": "Disease progression and comorbidities in lipedema patients: A 10‐year retrospective analysis",
      "authors": "Ghods et al.",
      "journal": "Dermatologic Therapy"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-sonnet-4.6",
    "question": "SQ-LIP-000007",
    "source": "europepmc",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "license": "CC-BY-4.0",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created"
    },
    {
      "date": "2026-05-31",
      "event": "corroborated_by_layer1",
      "detail": "DOI:10.1111/dth.14534"
    }
  ],
  "answers_questions": [
    {
      "id": "SQ-LIP-000007",
      "role": "supporting",
      "question": "Is lipedema associated with thyroid disease?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000007.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000134.html"
}