{
  "id": "SCR-LIP-000137",
  "statement": "In a Brazilian cross-sectional screening study, hypothyroidism was common in women with lipedema (crude prevalence 19.4%) but was NOT an independent factor associated with lipedema on multivariate analysis (p=0.141) — the raw co-occurrence may reflect confounding (e.g. by obesity) rather than a true independent association.",
  "statement_pt": "Em um estudo transversal brasileiro de rastreamento, o hipotireoidismo foi comum em mulheres com lipedema (prevalência bruta de 19,4%), mas NÃO foi fator independente associado ao lipedema na análise multivariada (p=0,141) — a coocorrência bruta pode refletir confundimento (p.ex., pela obesidade), não uma associação independente real.",
  "claim_type": "epidemiologic",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1590/1677-5449.202101982",
      "stance": "refines",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2022,
      "amato_authored": true,
      "note": "The article reports hypothyroidism prevalence in lipedema patients across different cohorts but does not statistically test the association between lipedema and thyroid disease as a primary outcome; the data are descriptive and based on sel",
      "title": "Lipedema prevalence and risk factors in Brazil",
      "authors": "Amato et al.",
      "journal": "Jornal Vascular Brasileiro"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": "DOI:10.1590/1677-5449.202101982",
  "curators": [
    {
      "name": "Alexandre C. M. Amato",
      "orcid": "0000-0003-4008-4029",
      "role": "lead_curator"
    }
  ],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-sonnet-4.6",
    "question": "SQ-LIP-000007",
    "source": "library",
    "ingested": "2026-05-31",
    "human_reviewed": true
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "license": "CC-BY-4.0",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created"
    }
  ],
  "answers_questions": [
    {
      "id": "SQ-LIP-000007",
      "role": "refines",
      "question": "Is lipedema associated with thyroid disease?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000007.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000137.html"
}