{
  "id": "SCR-LIP-000138",
  "statement": "This systematic review reports lipedema prevalence estimates of 11% in women (Földi), 15% of patients in a lymphology clinic (Herpertz), and 18.8% of 843 patients with lower-limb enlargement, occurring almost exclusively in women, with positive family history in 16–64% of cases.",
  "statement_pt": "Esta revisão sistemática relata estimativas de prevalência de lipedema de 11% em mulheres (Földi), 15% dos pacientes em clínica linfológica (Herpertz) e 18,8% de 843 pacientes com aumento dos membros inferiores, ocorrendo quase exclusivamente em mulheres, com histórico familiar positivo em 16–64% dos casos.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1111/j.1758-8111.2012.00045.x",
      "stance": "supporting",
      "study_design": "review",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2012,
      "amato_authored": false,
      "note": "The review directly compiles epidemiological data on lipedema prevalence, sex distribution (almost exclusively women), and familial occurrence, directly addressing how common lipedema is and who it affects.",
      "title": "Lipedema: an overview of its clinical manifestations, diagnosis and treatment of the disproportional fatty deposition syndrome – systematic review",
      "authors": "Forner‐Cordero et al.",
      "journal": "Clinical Obesity"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000002",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "license": "CC-BY-4.0",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created"
    }
  ],
  "answers_questions": [
    {
      "id": "SQ-LIP-000002",
      "role": "supporting",
      "question": "How common is lipedema, and who does it affect?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000002.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000138.html"
}