{
  "id": "SCR-LIP-000144",
  "statement": "In a cross-sectional study of 258 women with clinically diagnosed lipedema stratified by BMI, the prevalence of lower-limb clinical lymphedema rose from 6.1% (BMI <30) to 51.6% (BMI 30-40) to 77.8% (BMI 40-50), and subclinical systemic lymphedema from 16.3% to 48.3% to 72.2%, with a dose-response gradient by BMI.",
  "statement_pt": "Em um estudo transversal com 258 mulheres com diagnóstico clínico de lipedema estratificadas por IMC, a prevalência de linfedema clínico de membros inferiores aumentou de 6,1% (IMC <30) para 51,6% (IMC 30-40) e 77,8% (IMC 40-50), e o linfedema sistêmico subclínico de 16,3% para 48,3% e 72,2%, com gradiente dose-resposta conforme o IMC.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.7759/cureus.11854",
      "stance": "context",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2020,
      "amato_authored": false,
      "note": "The article describes a population of women with lipedema and reports prevalence figures within that population, but it studies the prevalence of lymphedema progression among lipedema patients rather than the general prevalence of lipedema ",
      "title": "Lipedema and the Evolution to Lymphedema With the Progression of Obesity",
      "authors": "Pereira de Godoy et al.",
      "journal": "Cureus"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000002",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "license": "CC-BY-4.0",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created"
    }
  ],
  "answers_questions": [
    {
      "id": "SQ-LIP-000002",
      "role": "context",
      "question": "How common is lipedema, and who does it affect?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000002.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000144.html"
}