{
  "id": "SCR-LIP-000145",
  "statement": "In a review citing a prior study of 160 lipedema patients, joint hypermobility was reported in over 50% of patients, and hypermobility associated with lipedema was noted as a risk factor for joint disease and aortic stiffness.",
  "statement_pt": "Em uma revisão que cita um estudo anterior com 160 pacientes com lipedema, a hipermobilidade articular foi relatada em mais de 50% dos pacientes, sendo a hipermobilidade associada ao lipedema apontada como fator de risco para doença articular e rigidez aórtica.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1515/hmbci-2017-0076",
      "stance": "supporting",
      "study_design": "review",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2018,
      "amato_authored": false,
      "note": "The narrative review reports a >50% prevalence of joint hypermobility among lipedema patients (citing prior data) and links hypermobility to lipedema, but provides no comparison group or adjusted analysis, so it offers only crude supportive",
      "title": "Lipedema: friend and foe",
      "authors": "Torre et al.",
      "journal": "Hormone Molecular Biology and Clinical Investigation"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000005",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "license": "CC-BY-4.0",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created"
    }
  ],
  "answers_questions": [
    {
      "id": "SQ-LIP-000005",
      "role": "supporting",
      "question": "Does lipedema increase the prevalence of joint hypermobility?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000005.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000145.html"
}