{
  "id": "SCR-LIP-000146",
  "statement": "An American consensus standard-of-care guideline reports that joint hypermobility occurs in approximately 50% of women with lipedema, consistent with hypermobile Ehlers-Danlos syndrome (hEDS), listed as a comorbidity (GRADE 1.9 [A]).",
  "statement_pt": "Uma diretriz americana de consenso de padrão de cuidado relata que a hipermobilidade articular ocorre em aproximadamente 50% das mulheres com lipedema, consistente com a síndrome de Ehlers-Danlos hipermóvel (hEDS), listada como comorbidade (GRADE 1.9 [A]).",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1177/02683555211015887",
      "stance": "supporting",
      "study_design": "review",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2021,
      "amato_authored": false,
      "note": "The guideline reports a 50% prevalence of joint hypermobility among women with lipedema as a comorbidity, but this is an unadjusted prevalence within a consensus guideline (Delphi/GRADE review) without a non-lipedema comparison group, so it",
      "title": "Standard of care for lipedema in the United States",
      "authors": "Herbst et al.",
      "journal": "Phlebology: The Journal of Venous Disease"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000005",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "license": "CC-BY-4.0",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created"
    }
  ],
  "answers_questions": [
    {
      "id": "SQ-LIP-000005",
      "role": "supporting",
      "question": "Does lipedema increase the prevalence of joint hypermobility?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000005.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000146.html"
}