{
  "id": "SCR-LIP-000153",
  "statement": "In a survey of 209 lipedema patients, symptom onset clustered in adolescence (mean age 16±9 years, 32.5% at ages 14-18), family history was common (affected grandmothers 35.4%, mothers 29.7%, aunts 23.0%), and 30.5% of premenopausal patients had sex-hormone imbalances, consistent with hormonal and hereditary contributions to lipedema onset.",
  "statement_pt": "Em uma pesquisa com 209 pacientes com lipedema, o início dos sintomas concentrou-se na adolescência (idade média 16±9 anos, 32,5% entre 14-18 anos), a história familiar foi comum (avós afetadas 35,4%, mães 29,7%, tias 23,0%) e 30,5% das pacientes pré-menopausa apresentavam desequilíbrio de hormônios sexuais, consistente com contribuições hormonais e hereditárias para o início do lipedema.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1097/prs.0000000000006280",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2019,
      "amato_authored": false,
      "note": "Cross-sectional survey reporting adolescent/hormonal onset timing and high familial prevalence, supporting hormonal and hereditary influence on lipedema onset, though descriptive without adjusted analysis.",
      "title": "New Insights on Lipedema: The Enigmatic Disease of the Peripheral Fat",
      "authors": "Bauer et al.",
      "journal": "Plastic & Reconstructive Surgery"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000012",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "license": "CC-BY-4.0",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created"
    }
  ],
  "answers_questions": [
    {
      "id": "SQ-LIP-000012",
      "role": "supporting",
      "question": "Do hormones and heredity influence the onset of lipedema?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000012.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000153.html"
}