{
  "id": "SCR-LIP-000155",
  "statement": "In a cross-sectional study of Saudi lipedema patients, 49% reported puberty and 22% reported pregnancy as perceived triggering events, and 46% had a positive family history (predominantly mothers and sisters).",
  "statement_pt": "Em um estudo transversal de pacientes sauditas com lipedema, 49% relataram a puberdade e 22% a gestação como eventos gatilho percebidos, e 46% apresentaram história familiar positiva (predominantemente mães e irmãs).",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1097/gox.0000000000006173",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2024,
      "amato_authored": false,
      "note": "Descriptive cross-sectional data report self-reported hormonal triggers (puberty, pregnancy) and substantial positive family history, bearing directly on hormonal and hereditary influences on lipedema onset. Evidence is based on patient sel",
      "title": "Characteristics and Clinical Features of Patients with Lipedema in Saudi Arabia: A Cross-sectional Comprehensive Assessment",
      "authors": "Alosaimi et al.",
      "journal": "Plastic and Reconstructive Surgery - Global Open"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000012",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "license": "CC-BY-4.0",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created"
    }
  ],
  "answers_questions": [
    {
      "id": "SQ-LIP-000012",
      "role": "supporting",
      "question": "Do hormones and heredity influence the onset of lipedema?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000012.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000155.html"
}