{
  "id": "SCR-LIP-000170",
  "statement": "In a survey of 98 Polish women with lipedema, all WHOQOL-BREF domains scored below general-population values (physical health 45.4, psychological 46.3, social relationships 50.4, environment 49.6 on 0-100), 59.2% had PHQ-9 scores >=10 indicating possible depression (mean PHQ-9 12.2), and core lipedema symptoms (Factor 1: leg heaviness, joint/tissue/muscle pain, swelling, stiffness) were the only significant predictor of worse quality of life (beta=-0.345, p=0.004, model explaining 23.5% of variance).",
  "statement_pt": "Em uma pesquisa com 98 mulheres polonesas com lipedema, todos os domínios do WHOQOL-BREF ficaram abaixo dos valores da população geral (saúde física 45,4, psicológica 46,3, relações sociais 50,4, ambiente 49,6 em escala 0-100), 59,2% tiveram PHQ-9 >=10 indicando possível depressão (média PHQ-9 12,2), e os sintomas centrais do lipedema (Fator 1: peso nas pernas, dor articular/tecidual/muscular, inchaço, rigidez) foram o único preditor significativo de pior qualidade de vida (beta=-0,345, p=0,004, modelo explicando 23,5% da variância).",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.1186/s12905-021-01174-y",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2021,
      "amato_authored": false,
      "note": "Cross-sectional online survey of women with lipedema directly measuring quality of life (WHOQOL-BREF) and depression (PHQ-9), with multivariate regression linking symptom burden to reduced QoL; directly addresses the question's affirmative  [grade capped moderate->low per curated Oxford N4]",
      "title": "Quality of life, its factors, and sociodemographic characteristics of Polish women with lipedema",
      "authors": "Dudek et al.",
      "journal": "BMC Women's Health",
      "_prov": {
        "grade_source": "bib_curated"
      }
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000020",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000020"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000020",
      "role": "supporting",
      "question": "How does lipedema affect quality of life, depression, and anxiety in affected patients?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000020.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000170.html"
}