{
  "id": "SCR-LIP-000171",
  "statement": "In this scoping review, lipedema patients showed reduced quality of life (EQ-5D-3L 66.1 vs 85 in the Dutch population; WHOQOL-BREF physical/mental domains below midpoint), depression prevalence of 22.7%-42%, 51.1% with mental disorders, and QoL strongly correlated with depression severity (r=-0.75).",
  "statement_pt": "Nesta revisão de escopo, pacientes com lipedema apresentaram qualidade de vida reduzida (EQ-5D-3L 66,1 vs 85 na população holandesa; domínios físico/mental do WHOQOL-BREF abaixo do ponto médio), prevalência de depressão de 22,7%-42%, 51,1% com transtornos mentais, e a QV correlacionou-se fortemente com a severidade da depressão (r=-0,75).",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.3390/ijerph181910223",
      "stance": "supporting",
      "study_design": "review",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "very_low",
      "year": 2021,
      "amato_authored": false,
      "note": "Scoping review synthesizing multiple studies directly reporting reduced quality of life, high depression/anxiety prevalence, and correlations with QoL in lipedema patients, directly addressing the question. [grade capped moderate->very_low per curated Oxford N6]",
      "title": "Lipoedema as a Social Problem. A Scoping Review",
      "authors": "Czerwińska et al.",
      "journal": "International Journal of Environmental Research and Public Health",
      "_prov": {
        "grade_source": "bib_curated"
      }
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000020",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000020"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000020",
      "role": "supporting",
      "question": "How does lipedema affect quality of life, depression, and anxiety in affected patients?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000020.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000171.html"
}