{
  "id": "SCR-LIP-000174",
  "statement": "In a cross-sectional survey of 245 women with lipedema, health-related stigma was significantly higher than in an age-matched general female population (Distress 49.5 vs 17.1–28.7; 65% with moderate/severe distress) and correlated negatively with all RAND-36 quality-of-life domains (strongest for social functioning r=−0.54 and emotional well-being r=−0.50), while greater perceived social support correlated positively with HRQoL.",
  "statement_pt": "Em um estudo transversal com 245 mulheres com lipedema, o estigma relacionado à saúde foi significativamente maior do que na população feminina geral pareada por idade (Distress 49,5 vs 17,1–28,7; 65% com comprometimento moderado/grave) e correlacionou-se negativamente com todas as dimensões de qualidade de vida do RAND-36 (mais forte para funcionamento social r=−0,54 e bem-estar emocional r=−0,50), enquanto maior suporte social percebido correlacionou-se positivamente com a HRQoL.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.1080/07399332.2025.2499487",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2025,
      "amato_authored": false,
      "note": "The article directly examines quality of life and emotional well-being in lipedema patients, reporting that higher stigma is associated with lower HRQoL and worse emotional functioning, supporting the question's affirmative direction regard [grade capped moderate->low per curated Oxford N4]",
      "title": "Health-related stigma, perceived social support, and their role in quality of life among women with lipedema",
      "authors": "Falck et al.",
      "journal": "Health Care for Women International",
      "_prov": {
        "grade_source": "bib_curated"
      }
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000020",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000020"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000020",
      "role": "supporting",
      "question": "How does lipedema affect quality of life, depression, and anxiety in affected patients?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000020.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000174.html"
}