{
  "id": "SCR-LIP-000178",
  "statement": "In 44 women with lipedema, median total SF-36 quality of life was 57.4/100 (lowest domains: general health 35, pain 47.5, social functioning 50, energy/fatigue 45), below historical healthy Polish population (61.6) and a prior lipedema cohort (59.3), and SF-36 scores did not differ by BMI or WHtR strata.",
  "statement_pt": "Em 44 mulheres com lipedema, a qualidade de vida total mediana pelo SF-36 foi de 57,4/100 (dimensões mais baixas: saúde geral 35, dor 47,5, funcionamento social 50, energia/fadiga 45), inferior à população polonesa saudável histórica (61,6) e a uma coorte prévia de lipedema (59,3), e os escores do SF-36 não diferiram entre os estratos de BMI ou WHtR.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1186/s12905-025-03834-9",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2025,
      "amato_authored": false,
      "note": "Cross-sectional study reporting SF-36 quality of life in lipedema patients showing reduced scores versus reference populations, directly bearing on the quality-of-life aspect of the question; however it does not assess depression or anxiety",
      "title": "Examining the characteristic features of lipedema and the usefulness of BMI and WHtR in clinical evaluation",
      "authors": "Czerwińska et al.",
      "journal": "BMC Women's Health"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000020",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000020"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000020",
      "role": "supporting",
      "question": "How does lipedema affect quality of life, depression, and anxiety in affected patients?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000020.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000178.html"
}