{
  "id": "SCR-LIP-000188",
  "statement": "A simplified 9-item self-applied screening questionnaire (derived from the validated QuASiL) based on clinical diagnostic criteria (post-pubertal women, bilateral symmetric fat deposit below the hip sparing feet, negative Stemmer and Godet signs, pain on palpation, spontaneous bruising) achieved diagnostic discrimination of AUC=0.912 for an individual 7-question predictive model and AUC=0.8615 for a total-score model against expert clinical diagnosis in 109 women (59 with lipedema, 50 without), with the item 'feeling something wrong in the legs' being most discriminative (OR=4.328).",
  "statement_pt": "Um questionário de rastreamento autoaplicável simplificado de 9 itens (derivado do QuASiL validado), baseado em critérios diagnósticos clínicos (mulheres pós-puberais, depósito gorduroso simétrico bilateral abaixo do quadril sem envolver pés, sinais de Stemmer e Godet negativos, dor à palpação, equimoses espontâneas), atingiu discriminação diagnóstica de AUC=0,912 no modelo preditivo individual de 7 perguntas e AUC=0,8615 no modelo por escore total contra o diagnóstico clínico de avaliador experiente em 109 mulheres (59 com lipedema, 50 sem), sendo o item 'sentir que algo está errado nas pernas' o mais discriminativo (OR=4,328).",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.1590/1677-5449.200114",
      "stance": "refines",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2020,
      "amato_authored": true,
      "note": "The article develops and validates a screening tool grounded in standard clinical diagnostic criteria for lipedema and reports diagnostic accuracy (AUC) against expert clinical reference, directly bearing on diagnostic criteria and their re [grade capped moderate->low per curated Oxford N4]",
      "title": "Criação de questionário e modelo de rastreamento de lipedema",
      "authors": "Amato et al.",
      "journal": "Jornal Vascular Brasileiro",
      "_prov": {
        "grade_source": "bib_curated"
      }
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000022",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000022"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000022",
      "role": "refines",
      "question": "What clinical criteria and stage/type classification systems are used to diagnose and grade lipedema, and how reliable are they?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000022.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000188.html"
}