{
  "id": "SCR-LIP-000189",
  "statement": "In a prospective cohort of 83 women diagnosed with lipedema using clinical criteria, lipedema was classified by clinical stage (most often stage 1, 39.8%) and type (most often type III, hips to ankles, 74.7%), and lymphoscintigraphic abnormality grade showed no significant association with clinical stage (p=0.142), type (p=0.505), Stemmer's sign (p=0.506), age, or BMI.",
  "statement_pt": "Em uma coorte prospectiva de 83 mulheres diagnosticadas com lipedema por critérios clínicos, o lipedema foi classificado por estágio clínico (mais frequente estágio 1, 39,8%) e tipo (mais frequente tipo III, quadris aos tornozelos, 74,7%), e o grau de alteração linfocintilográfica não se associou significativamente ao estágio clínico (p=0,142), tipo (p=0,505), sinal de Stemmer (p=0,506), idade ou IMC.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.1016/j.remn.2018.06.008",
      "stance": "context",
      "study_design": "cohort",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "moderate",
      "year": 2018,
      "amato_authored": false,
      "note": "The article applies clinical stage and type classification systems to a lipedema cohort and reports their lack of association with lymphoscintigraphic severity, providing contextual data on the classification systems used, though its primar",
      "title": "Hallazgos linfogammagráficos en pacientes con lipedema",
      "authors": "Forner-Cordero et al.",
      "journal": "Revista Española de Medicina Nuclear e Imagen Molecular"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000022",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000022"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000022",
      "role": "context",
      "question": "What clinical criteria and stage/type classification systems are used to diagnose and grade lipedema, and how reliable are they?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000022.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000189.html"
}