{
  "id": "SCR-LIP-000190",
  "statement": "In a prospective cohort of 138 lipedema and 111 lymphedema patients, a CART algorithm using three clinical variables—bruising, body disproportion, and non-swollen feet (cuffing sign)—classified patients with 100% accuracy; lipedema was characterized by symmetry (100%), spared feet (93.5%), pain (92%), bruising (90.6%), telangiectasias (89.9%), and family history (84.7%), and staged 1-4 (stage I 37.7%, II 34.8%, III 22.5%, IV 5.1%).",
  "statement_pt": "Em uma coorte prospectiva de 138 pacientes com lipedema e 111 com linfedema, um algoritmo CART usando três variáveis clínicas—hematomas, desproporção corporal e pés poupados (cuffing sign)—classificou pacientes com 100% de acurácia; o lipedema foi caracterizado por simetria (100%), pés poupados (93,5%), dor (92%), hematomas (90,6%), telangiectasias (89,9%) e história familiar (84,7%), e estadiado de 1 a 4 (estágio I 37,7%, II 34,8%, III 22,5%, IV 5,1%).",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.23736/s0392-9590.25.05207-1",
      "stance": "supporting",
      "study_design": "cohort",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "moderate",
      "year": 2025,
      "amato_authored": false,
      "note": "The article directly addresses clinical diagnostic criteria and the stage classification system (stages 1-4) used in lipedema, and quantifies the discriminative reliability of clinical features via a validated CART model, bearing directly o",
      "title": "Building evidence for diagnosis of lipedema: using a classification and regression tree (CART) algorithm to differentiate lipedema from lymphedema patients",
      "authors": "FORNER-CORDERO et al.",
      "journal": "International Angiology"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000022",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000022"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000022",
      "role": "supporting",
      "question": "What clinical criteria and stage/type classification systems are used to diagnose and grade lipedema, and how reliable are they?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000022.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000190.html"
}