{
  "id": "SCR-LIP-000212",
  "statement": "In two patients after bariatric surgery (gastric bypass with 62% excess weight loss; sleeve gastrectomy with 49% excess weight loss), lipedematous fat of the lower limbs persisted despite substantial weight loss, demonstrating resistance of lipedema fat to caloric deficit.",
  "statement_pt": "Em dois pacientes após cirurgia bariátrica (bypass gástrico com 62% de perda de excesso de peso; gastrectomia sleeve com 49% de perda de excesso de peso), a gordura lipedematosa dos membros inferiores persistiu apesar da perda de peso substancial, demonstrando resistência da gordura do lipedema ao déficit calórico.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "very_low",
  "evidence": [
    {
      "ref": "DOI:10.1016/j.soard.2016.04.013",
      "stance": "contradicting",
      "study_design": "case_series",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "very_low",
      "year": 2016,
      "amato_authored": false,
      "note": "Two case reports directly addressing whether bariatric-induced weight loss alters lipedema fat; both show persistence of lipedema fat despite significant weight loss, contradicting the affirmative that weight loss reduces lipedema fat volum",
      "title": "Lipedema in patients after bariatric surgery",
      "authors": "Bast et al.",
      "journal": "Surgery for Obesity and Related Diseases"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000024",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000024"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000024",
      "role": "contradicting",
      "question": "Does bariatric surgery or substantial weight loss alter lipedema fat volume or symptoms?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000024.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000212.html"
}