{
  "id": "SCR-LIP-000214",
  "statement": "In a case-control study using TaqMan genotyping, carriers of the IL-6 rs1800795 (-174G/C) G allele (CG+GG) had a 5.92-fold higher risk of lipedema versus non-carriers (CC) (OR=5.92, 95%CI 1.983–17.711, p<0.001), with samples in Hardy-Weinberg equilibrium.",
  "statement_pt": "Em um estudo caso-controle usando genotipagem TaqMan, portadores do alelo G do polimorfismo IL-6 rs1800795 (-174G/C) (CG+GG) tiveram risco 5,92 vezes maior de lipedema em comparação com não-portadores (CC) (OR=5,92, IC95% 1,983–17,711, p<0,001), com amostras em equilíbrio de Hardy-Weinberg.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.26355/eurrev_202003_20690",
      "stance": "supporting",
      "study_design": "case_control",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2020,
      "amato_authored": false,
      "note": "The article directly investigates a specific genetic variant (IL-6 rs1800795) in lipedema and reports an association (OR=5.92) with the G allele, directly addressing the question on genetic variants. Single small case-control study without "
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000025",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000025"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000025",
      "role": "supporting",
      "question": "What specific genetic variants or inheritance patterns have been identified in lipedema?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000025.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000214.html"
}