{
  "id": "SCR-LIP-000224",
  "statement": "In a rigorously defined UK lipedema cohort (n=130), onset was frequently associated with hormonal changes (puberty, pregnancy, menopause), and the first dedicated GWAS identified a suggestive genetic locus (rs1409440, OR_meta 2.01, P_meta 4×10⁻⁶) upstream of LHFPL6, replicated in an independent 100,000 Genomes cohort.",
  "statement_pt": "Em uma coorte britânica de lipedema rigorosamente definida (n=130), o início foi frequentemente associado a mudanças hormonais (puberdade, gestação, menopausa), e o primeiro GWAS dedicado identificou um locus genético sugestivo (rs1409440, OR_meta 2,01, P_meta 4×10⁻⁶) upstream de LHFPL6, replicado em uma coorte independente do 100.000 Genomes Project.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.1371/journal.pone.0274867",
      "stance": "supporting",
      "study_design": "cohort",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "moderate",
      "year": 2022,
      "amato_authored": false,
      "note": "The lipedema article directly reports hormonal triggers of onset and a heritable genetic association (GWAS locus near LHFPL6 with independent replication), supporting both hormonal and hereditary influence, though the genetic signal was onl",
      "title": "Investigation of clinical characteristics and genome associations in the ‘UK Lipoedema’ cohort",
      "authors": "Grigoriadis et al.",
      "journal": "PLOS ONE"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000012",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000012"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000012",
      "role": "supporting",
      "question": "Do hormones and heredity influence the onset of lipedema?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000012.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000224.html"
}