{
  "id": "SCR-LIP-000226",
  "statement": "A GWAS of an inferred lipedema phenotype in UK Biobank women identified 18 genome-wide significant loci (SNP heritability ~5.13%), including RSPO3 (OR=1.24), GRB14-COBLL1, VEGFA, and ADAMTS9 (some replicated in an independent clinically-diagnosed lipedema cohort), with genetic correlations to body fat, leptin levels, and age at menopause.",
  "statement_pt": "Um GWAS de um fenótipo lipedêmico inferido em mulheres do UK Biobank identificou 18 loci genome-wide significativos (herdabilidade SNP ~5,13%), incluindo RSPO3 (OR=1,24), GRB14-COBLL1, VEGFA e ADAMTS9 (alguns replicados numa coorte independente de lipedema clinicamente diagnosticado), com correlações genéticas com gordura corporal, níveis de leptina e idade da menopausa.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.1038/s41431-022-01231-6",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "moderate",
      "year": 2023,
      "amato_authored": false,
      "note": "This genome-wide association study identifies heritable genetic risk loci for a lipedema phenotype, directly supporting a hereditary influence; genetic correlations with leptin and age at menopause also touch on hormonal/endocrine links. Co",
      "title": "Genome-wide association study of a lipedema phenotype among women in the UK Biobank identifies multiple genetic risk factors",
      "authors": "Klimentidis et al.",
      "journal": "European Journal of Human Genetics"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000012",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000012"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000012",
      "role": "supporting",
      "question": "Do hormones and heredity influence the onset of lipedema?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000012.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000226.html"
}