{
  "id": "SCR-LIP-000236",
  "statement": "A GWAS of a UK lipedema cohort (n=130) identified a suggestive association (not genome-wide significant) at SNP rs1409440 (OR_meta 2.01; P_meta 4×10⁻⁶) located upstream of LHFPL6, a gene involved in lipoma formation, with additional support from an independent 100,000 Genomes replication cohort.",
  "statement_pt": "Um GWAS de uma coorte britânica de lipedema (n=130) identificou uma associação sugestiva (não significativa em nível genome-wide) no SNP rs1409440 (OR_meta 2,01; P_meta 4×10⁻⁶) localizado upstream de LHFPL6, gene envolvido na formação de lipomas, com suporte adicional de uma coorte de replicação independente do 100.000 Genomes Project.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1371/journal.pone.0274867",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2022,
      "amato_authored": false,
      "note": "Article reports a dedicated GWAS identifying a specific genetic locus (rs1409440 near LHFPL6) associated with lipedema, directly addressing the question; association is only suggestive due to small sample size.",
      "title": "Investigation of clinical characteristics and genome associations in the ‘UK Lipoedema’ cohort",
      "authors": "Grigoriadis et al.",
      "journal": "PLOS ONE"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000025",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000025"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000025",
      "role": "supporting",
      "question": "What specific genetic variants or inheritance patterns have been identified in lipedema?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000025.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000236.html"
}