{
  "id": "SCR-LIP-000249",
  "statement": "LIPLEG is a planned multicentre investigator-blinded RCT randomising 405 women with painful lipedema (2:1) to liposuction plus CDT versus CDT alone, with the primary endpoint being a ≥2-point pain reduction on the NRS at 12 months, but the article is a study protocol with no results yet (recruitment started December 2020; NCT04272827).",
  "statement_pt": "O LIPLEG é um ensaio clínico randomizado multicêntrico com investigador cego, planejado para randomizar 405 mulheres com lipedema doloroso (2:1) para lipoaspiração mais CDT versus CDT isolada, tendo como desfecho primário a redução da dor de ≥2 pontos na NRS aos 12 meses, mas o artigo é um protocolo de estudo sem resultados disponíveis (recrutamento iniciado em dezembro de 2020; NCT04272827).",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1186/s13063-021-05727-2",
      "stance": "context",
      "study_design": "rct",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2021,
      "amato_authored": false,
      "note": "This is a published RCT protocol directly designed to evaluate liposuction efficacy and safety in lipedema, but it reports no outcome data yet, so it provides methodological context rather than evidence supporting or contradicting the quest"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000013",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000013"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000013",
      "role": "context",
      "question": "Is liposuction effective and safe for lipedema?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000013.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000249.html"
}