{
  "id": "SCR-LIP-000268",
  "statement": "In a prospective cohort of 138 lipedema patients (median age 47.6 years), 85% reported a positive family history, 57% had symptom onset related to puberty (median onset age 14.8 years), and Type III (ankle-to-hip) involvement predominated at ~71%, with a median diagnostic delay exceeding 25 years.",
  "statement_pt": "Em uma coorte prospectiva de 138 pacientes com lipedema (idade mediana de 47,6 anos), 85% relataram história familiar positiva, 57% tiveram início dos sintomas relacionado à puberdade (idade mediana de início de 14,8 anos), e o tipo III (do tornozelo ao quadril) predominou em ~71%, com atraso diagnóstico superior a 25 anos.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.2458/lymph.4838",
      "stance": "supporting",
      "study_design": "cohort",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "moderate",
      "year": 2021,
      "amato_authored": false,
      "note": "The article reports demographic and onset characteristics of a lipedema patient cohort, including age, familial prevalence, pubertal onset, and diagnostic delay, which directly inform who lipedema affects and its patterns of occurrence."
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000002",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000002"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000002",
      "role": "supporting",
      "question": "How common is lipedema, and who does it affect?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000002.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000268.html"
}