{
  "id": "SCR-LIP-000277",
  "statement": "In non-obese lipedema patients, standardized QST (DFNS protocol) revealed selective alterations in only 2 of 13 parameters at the affected lateral thigh—elevated pressure pain (PPT, AUC 0.9075) and reduced vibration detection (VDT, AUC 0.8638)—and a combined PPT+VDT z-score score was proposed as a rapid diagnostic test for lipedema.",
  "statement_pt": "Em pacientes não-obesas com lipedema, o QST padronizado (protocolo DFNS) revelou alterações seletivas em apenas 2 de 13 parâmetros na coxa lateral afetada—hiper-responsividade à dor por pressão (PPT, AUC 0,9075) e redução da sensibilidade à vibração (VDT, AUC 0,8638)—e um escore combinado PPT+VDT foi proposto como teste diagnóstico rápido para lipedema.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1101/2023.04.25.23289086",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2023,
      "amato_authored": false,
      "note": "Cross-sectional case-control comparison proposing a quantitative sensory testing-based diagnostic score (PVTH-score) with high discriminative accuracy, directly addressing the development of a screening/diagnostic tool for identifying liped"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000004",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000004"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000004",
      "role": "supporting",
      "question": "Is lipedema underdiagnosed, and can screening tools help identify it?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000004.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000277.html"
}