{
  "id": "SCR-LIP-000283",
  "statement": "In a cohort of 83 women with clinically diagnosed lipedema, symptoms began at a mean age of 20.4 years but diagnosis occurred at a mean age of 46.5 years, indicating a mean diagnostic delay of 26.1 years, while lymphoscintigraphy showed lymphatic alterations in 47% of patients across all clinical stages.",
  "statement_pt": "Em uma coorte de 83 mulheres com diagnóstico clínico de lipedema, os sintomas começaram em média aos 20,4 anos, mas o diagnóstico ocorreu em média aos 46,5 anos, indicando atraso diagnóstico médio de 26,1 anos, enquanto a linfocintilografia mostrou alterações linfáticas em 47% das pacientes em todos os estágios clínicos.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1016/j.remn.2018.06.008",
      "stance": "context",
      "study_design": "cohort",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2018,
      "amato_authored": false,
      "note": "The article documents a substantial diagnostic delay (26.1 years on average), which contextually supports the notion that lipedema is underdiagnosed, but the study's primary aim concerns lymphoscintigraphic findings rather than evaluating s"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000004",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000004"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000004",
      "role": "context",
      "question": "Is lipedema underdiagnosed, and can screening tools help identify it?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000004.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000283.html"
}