{
  "id": "SCR-LIP-000285",
  "statement": "A systematic review reported that lipedema is poorly recognized clinically—only 46.2% of 251 Vascular Society of Great Britain and Ireland consultants recognized it (Tiwari 2006)—and that it was absent from MeSH/EMBASE and ICD-WHO as of 2012, while non-contrast CT showed 95% sensitivity and 100% specificity and the spared foot dorsum (negative Stemmer sign) helps distinguish lipedema from lymphedema.",
  "statement_pt": "Uma revisão sistemática relatou que o lipedema é mal reconhecido clinicamente—apenas 46,2% de 251 consultores da Vascular Society of Great Britain and Ireland o reconheciam (Tiwari 2006)—e que estava ausente do MeSH/EMBASE e do ICD-WHO em 2012, enquanto a TC sem contraste apresentou sensibilidade de 95% e especificidade de 100% e o sinal do dorso do pé poupado (Stemmer negativo) ajuda a diferenciar lipedema de linfedema.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.1111/j.1758-8111.2012.00045.x",
      "stance": "supporting",
      "study_design": "review",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "moderate",
      "year": 2012,
      "amato_authored": false,
      "note": "The review explicitly documents widespread under-recognition of lipedema (low clinician recognition rate, absence from coding systems, 'hidden epidemic') and describes diagnostic criteria and imaging tools (clinical staging, CT sensitivity/"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000004",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000004"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000004",
      "role": "supporting",
      "question": "Is lipedema underdiagnosed, and can screening tools help identify it?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000004.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000285.html"
}