{
  "id": "SCR-LIP-000288",
  "statement": "In a prospective cohort of 138 lipedema and 111 lymphedema patients, a CART algorithm using only three clinical variables (bruising, body disproportion, and non-swollen/spared feet) classified lipedema versus lymphedema with 100% accuracy, and the median time from symptom onset to diagnosis was markedly longer in lipedema (25.5 years vs 12.1 years for lymphedema, p<0.0001).",
  "statement_pt": "Em uma coorte prospectiva de 138 pacientes com lipedema e 111 com linfedema, um algoritmo CART utilizando apenas três variáveis clínicas (hematomas, desproporção corporal e pés poupados) classificou lipedema versus linfedema com 100% de acurácia, e o tempo mediano do início dos sintomas até o diagnóstico foi marcadamente maior no lipedema (25,5 anos vs 12,1 anos no linfedema, p<0,0001).",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.23736/s0392-9590.25.05207-1",
      "stance": "supporting",
      "study_design": "cohort",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "moderate",
      "year": 2025,
      "amato_authored": false,
      "note": "The article reports a chronic diagnostic delay in lipedema (25.5 years to diagnosis), supporting underdiagnosis, and develops a simple 3-variable screening/classification tree to identify lipedema versus lymphedema, directly addressing both"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000004",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000004"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000004",
      "role": "supporting",
      "question": "Is lipedema underdiagnosed, and can screening tools help identify it?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000004.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000288.html"
}